Abstract #2291
The Impact of Lung Disease on the Compartment-specific Uptake of Hyperpolarized 129Xe
Kai Ruppert 1,2 , Kun Qing 2 , Talissa A. Altes 2 , Jaime F. Mata 2 , Iulian C. Ruset 3,4 , F. William Hersman 3,4 , and John P. Mugler III 2
1
Cincinnati Children's Hospital, Cincinnati,
OH, United States,
2
University
of Virginia, Charlottesville, VA, United States,
3
Xemed
LLC, Durham, NH, United States,
4
University
of New Hampshire, Durham, NH, United States
"Chemical Shift Saturation Recovery" (CSSR) is a method
for monitoring the uptake of hyperpolarized xenon-129
(HXe) by lung parenchyma. The purpose of our studies was
to investigate differences in relative HXe uptake by red
blood cells (RBCs) versus lung tissue and plasma (TP) in
healthy subjects, asthmatics and COPD patients. We found
that the RBC-to-TP ratio (RTR) for 92% of the healthy
subjects fell into a narrow range. Two groups of
asthmatics, one with high and one with low RTRs could be
identified while all COPD patients exhibited abnormally
low RTRs.
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