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Abstract #2291

The Impact of Lung Disease on the Compartment-specific Uptake of Hyperpolarized 129Xe

Kai Ruppert 1,2 , Kun Qing 2 , Talissa A. Altes 2 , Jaime F. Mata 2 , Iulian C. Ruset 3,4 , F. William Hersman 3,4 , and John P. Mugler III 2

1 Cincinnati Children's Hospital, Cincinnati, OH, United States, 2 University of Virginia, Charlottesville, VA, United States, 3 Xemed LLC, Durham, NH, United States, 4 University of New Hampshire, Durham, NH, United States

"Chemical Shift Saturation Recovery" (CSSR) is a method for monitoring the uptake of hyperpolarized xenon-129 (HXe) by lung parenchyma. The purpose of our studies was to investigate differences in relative HXe uptake by red blood cells (RBCs) versus lung tissue and plasma (TP) in healthy subjects, asthmatics and COPD patients. We found that the RBC-to-TP ratio (RTR) for 92% of the healthy subjects fell into a narrow range. Two groups of asthmatics, one with high and one with low RTRs could be identified while all COPD patients exhibited abnormally low RTRs.

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