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Abstract #2290

Measurement of Pulmonary Perfusion and Gas Exchange using Hyperpolarized 129 Xe in a Rodent Model of Radiation-Induced Lung Injury

OZKAN DOGANAY 1,2 , MATTHEW FOX 3 , and GILES SANTYR 1,2

1 Western University, London, Ontario, Canada, 2 Robarts Research Institute, London, Ontario, Canada, 3 Thunder Bay Regional Research Institute, Ontario, Canada

We present a finite element approach for modeling hyperpolarized Xenon-129 gas exchange mechanism in the lungs. The gas exchange model interprets the chemically shift saturation recovery (CSSR) spectrum with respect to different gas exchange times to reveal functional information regarding pulmonary perfusion and diffusing capacity. In particularly, the simulation provides information about changes in the pulmonary tissue and capillaries due to radiation induced lung injury by taking advantage of unique chemical shifts of dissolved hyperpolarized Xenon-129 in pulmonary tissue and red blood cells. The model may also useful for investigating other forms of lung injury (eg. Ventilator-induced lung injury).

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