Abstract #2290
Measurement of Pulmonary Perfusion and Gas Exchange using Hyperpolarized 129 Xe in a Rodent Model of Radiation-Induced Lung Injury
OZKAN DOGANAY 1,2 , MATTHEW FOX 3 , and GILES SANTYR 1,2
1
Western University, London, Ontario, Canada,
2
Robarts
Research Institute, London, Ontario, Canada,
3
Thunder
Bay Regional Research Institute, Ontario, Canada
We present a finite element approach for modeling
hyperpolarized Xenon-129 gas exchange mechanism in the
lungs. The gas exchange model interprets the chemically
shift saturation recovery (CSSR) spectrum with respect
to different gas exchange times to reveal functional
information regarding pulmonary perfusion and diffusing
capacity. In particularly, the simulation provides
information about changes in the pulmonary tissue and
capillaries due to radiation induced lung injury by
taking advantage of unique chemical shifts of dissolved
hyperpolarized Xenon-129 in pulmonary tissue and red
blood cells. The model may also useful for investigating
other forms of lung injury (eg. Ventilator-induced lung
injury).
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