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Abstract #2289

Comprehensive structure/function MRI of cystic fibrosis

Scott K Nagle 1,2 , Laura C Bell 2 , Christopher J Francois 1 , Robert V Cadman 2 , Stanley J Kruger 2 , Andrew D Hahn 2 , and Sean B Fain 1,2

1 Radiology, University of Wisconsin, Madison, WI, United States, 2 Medical Physics, University of Wisconsin, Madison, WI, United States

MRI has significant potential advantages over CT for longitudinal surveillance of cystic fibrosis (CF) with respect to reduced radiation dose, ability to image regional function, and the potential for earlier detection of disease progression or treatment response. In this study, the performance of several MRI methods for the detection of cystic fibrosis (CF) lung disease were evaluated in comparison to CT reference standards. MRI included both functional (3He ventilation and dynamic contrast-enhanced perfusion) and anatomic/structural methods, including a 3D radial ultrashort echo time (UTE) approach. There were strong correlations between CT air trapping and He-3 MRI, perfusion MRI, and UTE MRI.

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