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Abstract #2292

REVISITING THE 129 XE RELAXATION RATE IN HUMAN BLOOD AND QUANTIFYING THE RELAXIVITY OF DEOXYHAEMOGLOBIN IN THE PRESENCE OF 129 XE

Graham Norquay 1 , General Leung 1 , Neil J Stewart 1 , Gillian M Tozer 2 , Jan Wolber 1,3 , and Jim M Wild 1

1 Academic Radiology, University of Sheffield, Sheffield, South Yorkshire, United Kingdom, 2 Oncology, University of Sheffield, South Yorkshire, United Kingdom, 3 GE Healthcare, Amersham, Buckinghamshire, United Kingdom

In this study, the 129 Xe relaxation rate in human blood was evaluated over a large range of blood oxygenations (sO2 = 0.02 to 1.00). The 129 Xe relaxation rate (R 1 ) in red blood cells was found to vary linearly as a function of blood oxygenation, where the mechanism believed to be responsible is Xe interactions with paramagnetic deoxyhaemoglobin. A linear fit of 129 Xe R 1 vs the concentration of deoxyhaemoglobin ([dHb]) yielded a dHb- 129 Xe relaxivity of 0.035 mM -1 s -1 . This linear relationship may be utilised in future studies involving Xe transport from the lungs to distal tissues, organs and tumours.

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