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Abstract #2276

Early Detection Of Smoking-Induced Pulmonary Alterations Using Hyperpolarized 3 He MRI Derived Alveolar Partial Pressure of Oxygen

Hooman Hamedani 1 , Stephen J. Kadlecek 1 , Masaru Ishii 2 , Yi Xin 1 , Hoora Shaghaghi 1 , Biao Han 1 , Sarmad Siddiqui 1 , Sarah Zarrin 3 , Milton Rossman 1 , and Rahim R. Rizi 1

1 University of Pennsylvania, Philadelphia, PA, United States, 2 Johns Hopkins University, Merryland, United States, 3 University of Pennsylvania, PA, United States

While hyperpolarized (HP) gas MRI has been used to estimate alveolar oxygen tension ( p A O 2 ) [1], it has not been systematically compared to Gold standard to assess its potential for monitoring disease progression and response to new therapies. In this work, we compare imaged p A O 2 to data produced via pulmonary function test, six-minute walk test, and St.-George Questionnaire.

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