Abstract #2277
In vivo MRI effectively monitors onset and progression of bleomycin-induced lung fibrosis in free-breathing mice
Greetje Vande Velde 1 , Tom Dresselaers 2 , Ellen De Langhe 2,3 , Jennifer Poelmans 2 , Rik Lories 2,3 , and Uwe Himmelreich 2
1
Imaging & Pathology, KU Leuven, Leuven,
Flanders, Belgium,
2
KU
Leuven, Flanders, Belgium,
3
UZ
Leuven, Flanders, Belgium
Longitudinal MRI may enable sensitive assessment of lung
fibrosis onset and progression in free-breathing mice,
without radiotoxicity concerns or invasive endpoint
measurements. We compared the potential of UTE and
self-gated MRI with a conventional respiratory triggered
pulse sequence to monitor lung fibrosis onset and
progression in the bleomycin-induced pulmonary fibrosis
mouse model. All three MRI protocols could sensitively
visualize and quantify lung disease onset and
progression in individual mice. In vivo MRI results
correlated strongly with CT and histological readouts
for lung fibrosis. MRI is therefore a safe and
non-invasive alternative to invasive methods for
screening novel anti-fibrotic therapies.
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