Abstract #2275
Reproducibility and Diffusion Direction Dependence of Helium-3 Lung Morphometry
James D Quirk 1 , Yulin V Chang 1 , and Dmitriy A Yablonskiy 1
1
Mallinckrodt Institute of Radiology,
Washington University School of Medicine, St. Louis, MO,
United States
Lung morphometry with hyperpolarized helium-3 MRI is a
highly sensitive technique for the non-invasive
measurement of alveolar microstructural parameters.
Herein, we establish the reproducibility and diffusion
direction dependence of this technique in five healthy
subjects. The values of all lung morphometry parameters
(including acinar duct radius, alveolar depth, and mean
chord length) were highly reproducible over the short
and long-term and did not depend upon the direction of
the applied diffusion gradient. Together, this provides
confidence for the use of helium-3 lung morphometry for
longitudinal studies and clinical trials.
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