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Abstract #2272

Delayed hepatic signal recovery on ferucarbotran-enhanced magnetic resonance images in a rat model with regional liver irradiation

Toshihiro Furuta 1,2 , Masayuki Yamaguchi 1 , Ryutaro Nakagami 1,3 , Masaaki Akahane 4 , Manabu Minami 5 , Kuni Ohtomo 4 , and Hirofumi Fujii 1

1 Division of Functional Imaging, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan, 2 Department of Radiology, Research Hospital, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo, Japan, 3 Department of Radiological Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Tokyo, Japan, 4 Department of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, 5 Department of Radiology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan

To investigate whether hepatic MR signal recovery in SPIO-enhanced MR imaging could be a marker for early diagnosis of irradiated areas, we investigated hepatic MR signal changes after X-irradiation to previously SPIO-accumulated rat livers and examined the relationship between hepatic MR signal and iron deposits. Sequential T 2 * -weighted MR images demonstrated signal recovery delay only in irradiated liver areas within 4 days. It seems that the signal recovery delay was due to SPIO-derived iron deposition because hepatic signal intensity negatively correlated with hepatic iron deposits. Hepatic signal recovery could be a novel diagnostic marker for the delineation of irradiated areas.

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