Abstract #2272
Delayed hepatic signal recovery on ferucarbotran-enhanced magnetic resonance images in a rat model with regional liver irradiation
Toshihiro Furuta 1,2 , Masayuki Yamaguchi 1 , Ryutaro Nakagami 1,3 , Masaaki Akahane 4 , Manabu Minami 5 , Kuni Ohtomo 4 , and Hirofumi Fujii 1
1
Division of Functional Imaging, Research
Center for Innovative Oncology, National Cancer Center
Hospital East, Kashiwa, Chiba, Japan,
2
Department
of Radiology, Research Hospital, The Institute of
Medical Science, The University of Tokyo, Minato-ku,
Tokyo, Japan,
3
Department
of Radiological Sciences, Graduate School of Human
Health Sciences, Tokyo Metropolitan University, Tokyo,
Japan,
4
Department
of Radiology, Graduate School of Medicine, The
University of Tokyo, Tokyo, Japan,
5
Department
of Radiology, Graduate School of Comprehensive Human
Sciences, University of Tsukuba, Ibaraki, Japan
To investigate whether hepatic MR signal recovery in
SPIO-enhanced MR imaging could be a marker for early
diagnosis of irradiated areas, we investigated hepatic
MR signal changes after X-irradiation to previously SPIO-accumulated
rat livers and examined the relationship between hepatic
MR signal and iron deposits. Sequential T
2
*
-weighted
MR images demonstrated signal recovery delay only in
irradiated liver areas within 4 days. It seems that the
signal recovery delay was due to SPIO-derived iron
deposition because hepatic signal intensity negatively
correlated with hepatic iron deposits. Hepatic signal
recovery could be a novel diagnostic marker for the
delineation of irradiated areas.
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