Abstract #2273
Hyperpolarized pyruvate allows early detection of lactate in real-time metabolism of acute liver failure rats
Laia Chavarria 1,2 , Jordi Romero-Gimnez 1,2 , Eva Monteagudo 3 , Juan Crdoba 1,2 , and Silvia Lope-Piedrafita 3,4
1
Liver Unit, Hospital Vall Hebron, Barcelona,
Barcelona, Spain,
2
Centro
de Investigacin Biomdica en Red de Enfermedades
Hepticas y Digestivas (CIBEREHD), Barcelona, Barcelona,
Spain,
3
Servei
de RMN, Universitat Autnoma de Barcelona, Cerdanyola
del Valls, Barcelona, Spain,
4
Centro
de Investigacin Biomdica en Red en Bioingeniera,
Biomateriales y Nanomedicina (CIBER-BBN), Barcelona,
Spain
Intracranial hypertension is a severe complication of
acute liver failure (ALF) secondary to brain edema. The
pathogenesis of cerebral edema in ALF is not clear but
it is known that energy metabolism alterations are
involved where a genesis of lactate seems to have an
important role. We have studied the dynamic synthesis of
brain metabolites using hyperpolarized 1-13C pyruvate in
a rat model of ALF. We have found that ALF rats have a
significant increase in the lactate/pyruvate ratio as
compared to Control rats. Also, the production rate of
lactate and alanine was higher in ALF rats.
This abstract and the presentation materials are available to members only;
a login is required.
Join Here
