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Abstract #2271

Drug Dissolution: Investigation of Different Fluor Containing Substances using 19 F-MRI

Janet Friedrich 1 , Julia Schrder 1 , Sarah Kindgen 2 , Stefan Fischer 1 , Mark Schuppert 1 , Karsten Gogoll 2 , Peter Langguth 2 , and Laura Maria Schreiber 1

1 Department of Radiology, Johannes Gutenberg University Medical Center, Mainz, Germany, 2 Institute of Pharmaceutical Technology and Biopharmacy, Johannes Gutenberg University, Mainz, Germany

The aim of the present work was the evaluation of different fluor containing substances in reference to their MR properties (relaxation times, signal intensity, spectra) and their potential usage in further investigations of drug dissolution processes. Perfluoro-15-crown-5-ether (PFCE), toothpaste jelly and two fluorinated alkanes were investigated. From MR side PFCE and SFA2 turned out to be the most attractive substances among the investigated compounds. However, the advantageous chemical properties assigned SFA2 as the most promising compound. Thus, a first tablet loaded with SFA2 was prepared and imaged.

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