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Abstract #2211

Accurate Mouse Kidney Morphology with Glomerulus-Targeted Contrast Agents

Edwin Baldelomar 1 , Scott Beeman 2 , Luise Cullen-McEwen 3 , Jennifer R Charlton 4 , John F. Bertram 3 , and Kevin M. Bennett 5

1 Department of Physics, University of Hawai'i at Manoa, Honolulu, Hawaii, United States, 2 Radiology, Washington University School of Medicine, St Louis, Missouri, United States, 3 Department of Anatomy and Developmental Biology, Monash University, Melbourne, Victoria, Australia, 4 University of Virginia Medical Center, Charlottesville, Virginia, United States, 5 Department of Biology, University of Hawai'i at Manoa, Honolulu, Hawaii, United States

MRI has previously been shown to be a viable tool to establish nephron endowment in intact kidneys using super paramagnetic, glomerulus specific, cationic ferritin (CF). Along with nephron number, glomerular size may also be measured be with MRI. This work takes into account susceptibility of super paramagnetic CF labeling in 3D T2* gradient echo MRI to correct volume measurements from MRI to establish accurate, non-invasive, kidney morphology measurements in mice.

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