Abstract #2211
Accurate Mouse Kidney Morphology with Glomerulus-Targeted Contrast Agents
Edwin Baldelomar 1 , Scott Beeman 2 , Luise Cullen-McEwen 3 , Jennifer R Charlton 4 , John F. Bertram 3 , and Kevin M. Bennett 5
1
Department of Physics, University of Hawai'i
at Manoa, Honolulu, Hawaii, United States,
2
Radiology,
Washington University School of Medicine, St Louis,
Missouri, United States,
3
Department
of Anatomy and Developmental Biology, Monash University,
Melbourne, Victoria, Australia,
4
University
of Virginia Medical Center, Charlottesville, Virginia,
United States,
5
Department
of Biology, University of Hawai'i at Manoa, Honolulu,
Hawaii, United States
MRI has previously been shown to be a viable tool to
establish nephron endowment in intact kidneys using
super paramagnetic, glomerulus specific, cationic
ferritin (CF). Along with nephron number, glomerular
size may also be measured be with MRI. This work takes
into account susceptibility of super paramagnetic CF
labeling in 3D T2* gradient echo MRI to correct volume
measurements from MRI to establish accurate,
non-invasive, kidney morphology measurements in mice.
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