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Abstract #2212

Multiparametric functional MRI for assessment of acute renal allograft rejection in mice correlation with renal histology and the composition of T-cell infiltrates

Katja Hueper 1,2 , Song Rong 3 , Marcel Gutberlet 1,2 , Matti Peperhove 1 , Susanne Tewes 1 , Amelie Barrmeyer 1 , Martin Meier 4 , Sibylle von Vietinghoff 3 , Michael Mengel 5 , Hermann Haller 3 , Frank Wacker 1,2 , Dagmar Hartung 1,2 , and Faikah Gueler 3

1 Radiology, Hannover Medical School, Hannover, Germany, 2 REBIRTH Cluster of Excellence, Hannover Medical School, Hannover, Germany, 3 Nephrology, Hannover Medical School, Hannover, Germany, 4 Institute of Animal Science, Hannover Medical School, Hannover, Germany, 5 Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, Alberta, Canada

We investigated whether multiparametric functional MRI allows evaluation of renal allograft rejection in mice. An acute rejection was induced by allogenic kidney transplantation; animals after isogenic transplantation were used as controls. Three weeks after transplantation renal perfusion (ASL), T1-/ T2-relaxation times and ADC-values were determined using a 7T-scanner. Animals after allogenic transplantation developed an acute T-cell-mediated rejection. In these animals, renal perfusion impairment was stronger, T1- and T2-values were higher and ADC was lower compared to animals after isogenic transplantation. Functional MRI-parameters significantly correlated with the extent of T-cell-infiltrates. Thus, functional MRI may improve non-invasive diagnosis of renal allograft rejection.

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