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Abstract #2210

New Magnetic Nanoparticle for Kidney Function

Yoshichika Yoshioka 1,2 , Ting Chen 1 , Yuki Mori 1,2 , Zhenyu Cheng 1 , Yuuto Kashiwagi 1 , Masaki Fukunaga 2,3 , Ikuhiro Kida 1,2 , Yoshiyuki Tago 4 , Shinichi Yoshida 4 , and Kohji Ohno 5

1 Immunology Frontier Research Center (IFReC), Osaka University, Suita, Osaka, Japan, 2 Center for Information and Neural Networks (CiNet), National Institute of Information and Communications Technology (NICT) and Osaka University, Suita, Osaka, Japan, 3 1Immunology Frontier Research Center (IFReC), Osaka University, Suita, Osaka, Japan, 4 Frontier Biochemical and Medical Research Laboratories, Kaneka Corporation, Takasago, Hyogo, Japan, 5 Institute for Chemical Research, Kyoto University, Uji, Kyoto, Japan

The biodistribution pattern of newly synthesized magnetic nano particles was investigated in mice. The particles are taken little by Kupffer cells and peripheral macrophages and have the long half-life in mouse blood circulation. The particles showed the marked distribution pattern especially in the mouse kidney. The particles retained much in the renal cortex and in the boundaries between cortex and medulla and between outer medulla and inner medulla. The dark round spots in the renal cortex were confirmed as renal corpuscles. These distribution patterns could be used as a measure of renal functions.

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