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Abstract #2209

Effect of Anesthesia on Renal R 2 * Measured by BOLD MRI

David J Niles 1 , Jeremy W Gordon 1 , and Sean B Fain 1,2

1 Medical Physics, University of Wisconsin, Madison, WI, United States, 2 Radiology, University of Wisconsin, Madison, WI, United States

Anesthesia produces several physiologic effects in the kidney, including changes of blood flow, glomerular filtration, and sodium excretion. Because R 2 * is influenced by hemodynamic parameters and oxygenation, its value may differ depending on the choice and dosage of anesthetic agent used during imaging. We measured renal R 2 * in mice anesthetized with five common anesthetics and observed strong dependence of R 2 * on the choice of agent. Differences in R 2 * between inhaled and injected agents was not explained by differences in inspired oxygen fraction. We conclude that the effects of anesthetic agent should be considered when designing and evaluating BOLD MRI studies.

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