Abstract #2209
Effect of Anesthesia on Renal R 2 * Measured by BOLD MRI
David J Niles 1 , Jeremy W Gordon 1 , and Sean B Fain 1,2
1
Medical Physics, University of Wisconsin,
Madison, WI, United States,
2
Radiology,
University of Wisconsin, Madison, WI, United States
Anesthesia produces several physiologic effects in the
kidney, including changes of blood flow, glomerular
filtration, and sodium excretion. Because R
2
*
is influenced by hemodynamic parameters and oxygenation,
its value may differ depending on the choice and dosage
of anesthetic agent used during imaging. We measured
renal R
2
* in mice anesthetized with five
common anesthetics and observed strong dependence of R
2
*
on the choice of agent. Differences in R
2
*
between inhaled and injected agents was not explained by
differences in inspired oxygen fraction. We conclude
that the effects of anesthetic agent should be
considered when designing and evaluating BOLD MRI
studies.
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