Abstract #2203
Non-invasively Quantitative Measurements of Intrarenal Oxygen Extraction Fraction (OEF) in Rabbits with Unilateral Renal Artery Stenosis Using MRI
Xiaodong Zhang 1 , Yue Mi 2 , Jing Wang 3 , Jingyun Wu 1 , Kai Zhao 1 , Jian Luo 1 , Xuedong Yang 1 , Xiaoying Wang 1,4 , Jue Zhang 4 , and Hongyu An 5
1
Department of Radiology, Peking University
First Hospital, Beijing, Beijing, China,
2
Department
of Urology, Peking University First Hospital, Beijing,
Beijing, China,
3
School
of physics, Peking University, Beijing, Beijing, China,
4
Academy
for Advanced Interdisciplinary Studies, Peking
University, Beijing, Beijing, China,
5
Department
of Radiology and Biomedical Research Imaging Center,
University of North Carolina at Chapel Hill, Chapel
Hill, NC, United States
Quantitative measurement of renal oxygenation is of
central importance in understanding and treating renal
diseases and oxygen extraction fraction (OEF) can
provide a valid criterion for evaluation the tissue
oxygen metabolism under both normal and disease states.
According to the Yablonskiy and Haackes biophysical
analytical model, the intra-renal OEF can be estimated
using a multi-echo gradient and spin echo (MEGSE)
sequence. In this study, we will demonstrate the ability
to obtain quantitative estimates of intra-renal OEF
noninvasively in normal and unilateral renal artery
stenosis rabbits of the Multi-Echo Gradient and Spin
Echo (MEGSE).
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