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Abstract #2204

Ferumoxytol Enhanced Steady-State MRI Reveals Renal Blood Volume Decrease During Aortic Occlusion

Andreas Pohlmann 1 , Jan Hentschel 1 , Karen Arakelyan 1 , Stefanie Kox 1 , Sonia Waiczies 1 , Bert Flemming 2 , Erdmann Seeliger 2 , and Thoralf Niendorf 1

1 Berlin Ultrahigh Field Facility, Max Delbrueck Center for Moleculare Medicine, Berlin, Germany, 2 Institute of Physiology and Center for Cardiovascular Research, Charit Medical Faculty, Berlin, Germany

Acute kidney injuries (AKI) of various origins share one common feature: imbalance between local tissue oxygen delivery and demand. Changes in tissue pO2 and T2* may be closely related, however, their link could be influenced by variations in blood volume fraction. We hypothesized that monitoring of RBV could provide evidence for a significant RBV reduction during aortic occlusion, and hence for the relevance of RBV when interpreting renal T2*. To test our hypothesis we established RBV estimation with ferumoxytol at 9.4 Tesla in rats and compared the effects of renal arterio-venous occlusion with suprarenal aortic occlusion while monitoring renal T2*.

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