Abstract #2204
Ferumoxytol Enhanced Steady-State MRI Reveals Renal Blood Volume Decrease During Aortic Occlusion
Andreas Pohlmann 1 , Jan Hentschel 1 , Karen Arakelyan 1 , Stefanie Kox 1 , Sonia Waiczies 1 , Bert Flemming 2 , Erdmann Seeliger 2 , and Thoralf Niendorf 1
1
Berlin Ultrahigh Field Facility, Max
Delbrueck Center for Moleculare Medicine, Berlin,
Germany,
2
Institute
of Physiology and Center for Cardiovascular Research,
Charit Medical Faculty, Berlin, Germany
Acute kidney injuries (AKI) of various origins share one
common feature: imbalance between local tissue oxygen
delivery and demand. Changes in tissue pO2 and T2* may
be closely related, however, their link could be
influenced by variations in blood volume fraction. We
hypothesized that monitoring of RBV could provide
evidence for a significant RBV reduction during aortic
occlusion, and hence for the relevance of RBV when
interpreting renal T2*. To test our hypothesis we
established RBV estimation with ferumoxytol at 9.4 Tesla
in rats and compared the effects of renal arterio-venous
occlusion with suprarenal aortic occlusion while
monitoring renal T2*.
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