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Abstract #2201

Quantitative Assessment of Renal T2* Heterogeneity with Minkowski Functionals for the Detection of Ischemia/Reperfusion Injury

Andreas Pohlmann 1 , Jan Hentschel 1 , Karen Arakelyan 1 , Mandy Fechner 2 , Uwe Hoff 2 , Gordana Bubalo 2 , Kathleen Cantow 3 , Sonia Waiczies 1 , Duska Dragun 2 , Bert Flemming 3 , Erdmann Seeliger 3 , and Thoralf Niendorf 1

1 Berlin Ultrahigh Field Facility, Max Delbrueck Center for Moleculare Medicine, Berlin, Germany, 2 Nephrology and Intensive Care Medicine, Campus Virchow-Klinikum and Center for Cardiovascular Research, Charite-Universitaetsmedizin Berlin, Berlin, Germany, 3 Institute of Physiology and Center for Cardiovascular Research, Charit Medical Faculty, Berlin, Germany

Imbalance between renal tissue oxygen demand and supply is a pivotal element in the pathophysiologic cascade of ischema/reperfusion injury. Parametric mapping of renal T2*, which is known to be blood oxygenation level dependent, to monitor I/R in rats if feasible, however, comparison of absolute renal T2* is barely feasible, because absolute values depend on magnetic field strength, B0 homogeneity, etc. By applying image heterogeneity analysis by 2D Minkowski functionals to renal T2* data we investigated whether renal T2* heterogeneity analysis allows a differentiation between healthy nave kidneys, ischemic kidneys, and kidneys during subsequent reperfusion.

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