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Abstract #2200

Imaging Glomeruli in a Clinical MRI System at 3 T

Jorge Chacn-Caldera 1 , Philipp Krmer 1 , Sebastian Domsch 1 , Stefania Geraci 2 , Norbert Gretz 2 , and Lothar R Schad 1

1 Computer Assisted Clinical Medicine, Heidelberg University, Mannheim, Germany, 2 Medical Research Center, Heidelberg University, Mannheim, Germany

The number of glomeruli in kidneys is associated with kidney diseases. There is interest to discover if glomerular quantification in humans is possible. Currently, glomerular imaging with MRI is achieved using in vitro samples in preclinical systems with main magnetic fields of minimum 7T. This work presents the first ever glomerular images acquired with a clinical scanner at 3T. We used two cationazed-ferritin labeled rat kidneys and a Siemens Magnetom to demonstrate that currently available clinical scanners are capable of performing glomerular imaging. The parameters were also used to assess the current standpoint towards future human kidney measurements.

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