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Abstract #2199

Evaluation of the temporal variation of diffusion and micro-perfusion in cisplatin induced rodent renal fibrosis models using multi-b diffusion weighted MR imaging

Haoran Sun 1 , Huanhuan Wu 1 , and Ziheng Zhang 2

1 Radiology, Tianjin Medical University Hospital, Tianjin, Tianjin, China, 2 MR Research China, GE Healthcare, Shanghai, Shanghai, China

Intravoxel incoherent motion (IVIM) DWI has recently shown potential to assess functional changes of renal fibrosis. From the findings through multi-b DW-MRI measurements on cisplatin induced rodent renal fibrosis models, the temporal variation of ADC values behaved as a weight of the true diffusion and pseudo-diffusion. The biomarkers resulted from mono-exponential model exhibited a dual phase temporal variation, while those from bi-exponential model remained a single tendency of variation. According to the histopathological observation that the worsening of renal fibrosis with time, the bi-exponential model might be a better choice for an accurate indication of the evolution of renal fibrosis.

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