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Abstract #2198

Ultra Low Dose Free breathing Quantitative Renal Perfusion and Filtration using 3D Through-time Radial GRAPPA

Katherine L. Wright 1 , Yong Chen 2 , Mark A. Griswold 1,2 , Nicole Seiberlich 1 , and Vikas Gulani 1,2

1 Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, United States, 2 Radiology, Case Western Reserve University, Cleveland, Ohio, United States

This work demonstrates 3D quantitative renal DCE MRI using half and quarter doses (by weight) of a gadolinium based contrast agent and no breath-holds. Data are acquired with a highly accelerated stack-of-stars acquisition, reconstructed using 3D through-time radial GRAPPA, and registered to remove respiratory motion. This exam provides 3D quantification of perfusion, filtration, and mean transit times at clinically relevant spatial resolutions using very low doses of contrast agent.

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