Abstract #2155
Distinction between non-advanced and advanced liver fibrosis: Comparison between MR DCE imaging and T2-corrected IVIM at 3.0T.
Benjamin LEPORQ 1 , Frank Pilleul 2,3 , Jerome Dumortier 4 , Olivier Guillaud 4 , Thibaud Lefort 5 , Pierre-Jean Valette 5 , and Olivier Beuf 2
1
Center for research on inflammation,
Universit PARIS 7 ; INSERM U1149, Paris, France,
2
CREATIS
CNRS UMR 5220; INSERM U1044; INSA Lyon; UCBL Lyon 1,
Universite de Lyon, Villeurbanne, France,
3
Centre
de lutte contre le cancer, Centre Lon Berard, Lyon,
France,
4
CHU
Edouard Herriot; Department of hepatology, Hospices
Civils de Lyon, Lyon, France,
5
CHU
Edouard Herriot; Department of gastro-intestinal
imaging, Hospices Civils de Lyon, Lyon, France
Our objective was to evaluate T2-corrected IVIM and
perfusion imaging using a MR-DCE technique for the
distinction between non-advanced and advanced fibrosis
in patients with chronic liver diseases. The link
between perfusion-related diffusion given by IVIM and
quantitative perfusion parameters given by MR-DCE
imaging was investigated. Results indicated that the
combination of IVIM and MR-DCE imaging do not bring
additional information for fibrosis assessment in a
large spectra of etiologies. Indeed, perfusion
parameters given by MR-DCE imaging alone are relevant to
evaluate fibrosis severity. Strong correlation between
portal perfusion and perfusion related diffusion
coefficient illustrated that IVIM reflects the
hemodynamic changes occurring in fibrous damage. Pure
molecular diffusion coefficient was affected by the
deposition of extracellular matrix components and by fat
vesicle suggesting that fat overload can constitute a
confounding factor in fibrosis assessment with IVIM.
Nevertheless, if fat overload is addressed, IVIM could
be a useful injection-free method to distinguish between
non-advanced and advanced fibrosis.
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