Abstract #2156
Imaging Liver Fibrosis and Response to Rapamycin Therapy
Christian T. Farrar 1 , Bryan C. Fuchs 2 , Helen Day 1 , Nicholas Rotile 1 , Danielle DePeralta 2 , Arun Subramaniam 3 , Kenneth K. Tanabe 2 , and Peter Caravan 1
1
Department of Radiology, Massachusetts
General Hospital and Harvard Medical School,
Charlestown, MA, United States,
2
Surgical
Oncology Division, Massachusetts General Hospital and
Harvard Medical School, Boston, MA, United States,
3
Sanofi-Aventis,
Bridgewater, NJ, United States
There is a critical unmet medical need for non-invasive
methods for quantifying liver fibrosis to facilitate
early diagnosis, monitor disease progression, and assess
response to therapies. Here we demonstrate the use of
the collagen-targeted contrast agent EP-3533 to monitor
progression of liver fibrosis in a bile duct ligation
rat model of liver fibrosis and to assess response to
rapamycin therapy.
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