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Abstract #2154

Accuracy of Hepatic Fibrosis Staging Using T2-WI and Texture Analysis

Karen Buch 1 , Baojun Li 2 , Hei Shun Yu 2 , Brian Tischler 3 , Naznin Daginawala 3 , and Stephan Anderson 4

1 Radiology, Boston University Medical Center, Boston, MA, United States, 2 Boston University Medical Center, Boston, United States, 3 Boston University Medical Center, MA, United States, 4 Radiology, Boston University Medical Center, Boston, United States

The purpose of this study was to evaluate the accuracy of texture analysis applied to T2-weighted images to assess hepatic fibrosis using a linear discriminant analysis. A total of 27 patients with varying grades of biopsy-proven hepatic fibrosis were analyzed with a sensitivity of up to 90% and specificity of 88% for GLCM entropy versus energy texture parameters. The development of accurate, non-invasive methods for the assessment and staging of liver fibrosis is crucial given a growing global impact of chronic liver disease and fibrosis. The application of texture analysis tools using T2-weighted images, possibly as part of a multi-parametric approach, affords the possibility of developing an accurate, noninvasive assessment of hepatic fibrosis.

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