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Abstract #2153

The repeatability of the Magnetic Resonance Elastography derived stiffness value in the liver

Alexander D Cohen 1 , Mark D Hohenwalter 2 , and Kathleen M Schmainda 1,2

1 Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States, 2 Radiology, Medical College of Wisconsin, Milwaukee, WI, United States

Magnetic Resonance Elastography (MRE) has gained prominence for its ability to stage liver fibrosis. MRE measures the propagation of acoustic shear waves, generated by a passive driver, through liver tissue. MRE gives estimates of liver stiffness, which have directly correlated with fibrosis grade in preliminary studies. MRE repeatability was assessed in a cohort of normal volunteers and cirrhotic patients imaged twice in one scanning session. Repeatability was excellent for both the volunteers and cirrhotic patients, and indicate changes must be larger than ~10% to be significant for longitudinal studies and ~10-30% to be significant for between group studies.

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