Abstract #2105
Structural and vascular changes in rats exposed to chronic intermittent hypoxia
Bianca Gonzales Cerqueira 1 , Shiliang Huang 1 , Glenn M. Toney 2 , and Timothy Q. Duong 1
1
Research Imaging Institute, Univ. of Texas
Health Science Center at San Antonio, San Antonio, TX,
United States,
2
Physiology,
Univ. of Texas Health Science Center at San Antonio, San
Antonio, TX, United States
Sleep apnea is correlated with cardiovascular disease
and cognitive deficits. Exposure to chronic intermittent
hypoxia (CIH) is used to model sleep apnea. Rats
underwent CIH for 14 or 28 days. CIH reduced basal CBF
for all ROIs, significantly in the somatosensory cortex
for 28-day CIH. CIH did not affect ADC or CBF response
to oxygen challenge and hypercapnia. FA values decreased
significantly in the somatosensory cortex and thalamus.
We have demonstrated the use of MRI to evaluate
structural and vascular changes in animals exposed to
CIH consistent with results found in patients with sleep
apnea.
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