Abstract #2106
Ex Vivo MR microscopic imaging identifies multiple neuroanatomical correlates of functional motor deficits in a rat model of bilirubin encephalopathy
Martin Herbert Schaffhauser 1,2 , Dominik Maria Reisinger 1,2 , Joel Marx 1 , Michael Porambo 1 , Jiangyang Zhang 3 , Michael V Johnston 1 , and Seyed Ali Fatemi 1,2
1
Neuroscience, Hugo W. Moser Research
Institute at Kennedy Krieger, Baltimore, MD, United
States,
2
Neurology,
Johns Hopkins University School of Medicine, Baltimore,
MD, United States,
3
Radiology,
Johns Hopkins University School of Medicine, Baltimore,
MD, United States
Despite the preventable nature of bilirubin
encephalopathy, cases continue to occur and remain a
significant problem in newborns. The Gunn rat is a rat
model, featuring an enzyme deficiency resembling Crigler
Najjar syndrome. Sulfadimethoxine was used to exaggerate
bilirubin encephalopathy, leading to a dystonic
phenotype. We evaluated the model in the chronic phase
ex vivo through acquiring high-resolution images of
T2-weighted sequences as well as DTI. While there were
no FA changes, we show decreased cerebellar volumes in
all mutant rats as well as decreased GP, ICP and MCP
volumes in the dystonic animals.
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