Meeting Banner
Abstract #2106

Ex Vivo MR microscopic imaging identifies multiple neuroanatomical correlates of functional motor deficits in a rat model of bilirubin encephalopathy

Martin Herbert Schaffhauser 1,2 , Dominik Maria Reisinger 1,2 , Joel Marx 1 , Michael Porambo 1 , Jiangyang Zhang 3 , Michael V Johnston 1 , and Seyed Ali Fatemi 1,2

1 Neuroscience, Hugo W. Moser Research Institute at Kennedy Krieger, Baltimore, MD, United States, 2 Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3 Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Despite the preventable nature of bilirubin encephalopathy, cases continue to occur and remain a significant problem in newborns. The Gunn rat is a rat model, featuring an enzyme deficiency resembling Crigler Najjar syndrome. Sulfadimethoxine was used to exaggerate bilirubin encephalopathy, leading to a dystonic phenotype. We evaluated the model in the chronic phase ex vivo through acquiring high-resolution images of T2-weighted sequences as well as DTI. While there were no FA changes, we show decreased cerebellar volumes in all mutant rats as well as decreased GP, ICP and MCP volumes in the dystonic animals.

This abstract and the presentation materials are available to members only; a login is required.

Join Here