Abstract #2104
BOLD response to forepaw stimulation in rats exposed to chronic intermittent hypoxia
Bianca Gonzales Cerqueira 1 , Shiliang Huang 1 , Glenn M. Toney 2 , and Timothy Q. Duong 1
1
Research Imaging Institute, Univ. of Texas
Health Science Center at San Antonio, San Antonio, TX,
United States,
2
Physiology,
Univ. of Texas Health Science Center at San Antonio, San
Antonio, TX, United States
This study evaluated the effects of chronic intermittent
hypoxia (CIH) on basal CBF and stimulus-evoked responses
in animals exposed to 14 and 28 days of CIH. We found
that BOLD and CBF activations in response to forepaw
stimulation trended toward a reduction with increasing
CIH exposure duration, although did not reach
statistical significance. Basal CBF in the somatosensory
cortex decreased with increasing CIH exposure,
significantly when controls were compared to 28 day CIH
animals. There were no changes in cerebral rate of
oxygen consumption, M value, or CBF response to
hypercapnia among the groups.
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