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Abstract #2103

Chronic High Altitude induced Apparent Diffusion Coefficient changes in Rat Hippocampus

Sunil Koundal 1 , Sonia Gandhi 1 , Tanzeer Kaur 2 , Richa Trivedi 1 , Rajendra P Tripathi 1 , and Subash Khushu 1

1 NMR Research Centre, Institute of Nuclear Medicine and Allied Sciences (INMAS), Timarpur, Delhi, India, 2 Department of Biophysics, Panjab University, Chandigarh, India

Effect of high altitude exposure on water diffusion in brain hippocampus region was studied with the help of Diffusion Weighted Imaging by calculating Apparent Diffusion Coefficient (ADC) values from the region of interest. It was found that high altitude hypoxic stress had an effect on water diffusion properties in hippocampal region. There was significant decrease in ADC values after 14 days of high altitude stress in CA2/3 and Dentate gyrus (Dg) region of hippocampus while CA1 showed significant decrease after 21 days of stress. Decrease in ADC value depicted cytotoxic edema indicating changes in tissue architecture at micro structural level.

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