Abstract #2103
Chronic High Altitude induced Apparent Diffusion Coefficient changes in Rat Hippocampus
Sunil Koundal 1 , Sonia Gandhi 1 , Tanzeer Kaur 2 , Richa Trivedi 1 , Rajendra P Tripathi 1 , and Subash Khushu 1
1
NMR Research Centre, Institute of Nuclear
Medicine and Allied Sciences (INMAS), Timarpur, Delhi,
India,
2
Department
of Biophysics, Panjab University, Chandigarh, India
Effect of high altitude exposure on water diffusion in
brain hippocampus region was studied with the help of
Diffusion Weighted Imaging by calculating Apparent
Diffusion Coefficient (ADC) values from the region of
interest. It was found that high altitude hypoxic stress
had an effect on water diffusion properties in
hippocampal region. There was significant decrease in
ADC values after 14 days of high altitude stress in
CA2/3 and Dentate gyrus (Dg) region of hippocampus while
CA1 showed significant decrease after 21 days of stress.
Decrease in ADC value depicted cytotoxic edema
indicating changes in tissue architecture at micro
structural level.
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