Abstract #2099
Neurofunctional and neurochemical endophenotypes in mouse models of autism spectrum disorder investigated by fMRI and MRS
Marija M. Petrinovic 1,2 , Michael Saxe 1 , Barbara Biemans 1 , Peter Scheiffele 2 , Markus von Kienlin 1 , and Basil Knnecke 1
1
F. Hoffmann-La Roche Ltd, Pharma Research &
Early Development, DTA Neuroscience, Basel, Basel,
Switzerland,
2
Biocenter,
University of Basel, Basel, Basel, Switzerland
Alterations in neural function and neurochemistry have
been proposed as mechanisms underlying behavioural
deficits associated with autism spectrum disorder (ASD).
We have leveraged fMRI/MRS in five mouse models of ASD
to bridge the gap between genetic/molecular findings and
behavioural phenotypes. fMRI revealed prominent
neurofunctional alterations in brain regions implicated
in socio-emotional, cognitive and sensorimotor
processing. fMRI fingerprints were heterogeneous across
the models, yet, they reflect the complexity of ASD
symptoms found in patients. 1H-MRS in these models
showed consistent changes in cerebral glutamate levels
indicative of a dysbalance in excitatory/inhibitory
neurotransmission which has been purported as a
substrate for ASD.
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