Abstract #2098
Age-dependent decrease of capillary density in arcAbeta mouse model of cerebral amyloidosis detected with relaxation rate shift index Q mapping at 9.4T using a cryoprobe
Giovanna Diletta Ielacqua 1 , Felix Schlegel 1 , Markus Rudin 2 , and Jan Klohs 1
1
Institute for Biomedical Engineering, ETH,
Zurich, Zurich, Switzerland,
2
Institute
for Biomedical Engineering, Institute of Pharmacology
and Toxicology, Zurich, Switzerland
It has been shown that in Alzheimers Disease amyloid
deposition in cerebral microvessels plays an important
role in cerebral perfusion. In this MRI study we
investigated capillary density through relaxation rate
shift index Q, and perfusion with bolus tracking . All
measurements were performed on a 9.4T scanner equipped
with a cryogenic phased-array coil, recording a 2D Spin
Echo-RARE, a 3D Gradient Echo-FLASH and an EPI sequence.
Our results show there is a decrease of capillary
density and cortical perfusion in 24months-old arcA
mice, suggesting that the index Q is a reliable
indicator of capillary density in brain
microvasculopathies
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