Abstract #2100
Characterization of age-dependent brain atrophy in presymptomatic YAC128 Huntington disease mice
Ling Guo 1 , Xuan Vinh To 1 , Xin Hong 1 , Reshmi Rajendran 1 , Si Kang Lew 1 , Yee Ling Tan 1 , Yihui Huang 2 , Michael R. Hayden 2,3 , Mahmoud A. Pouladi 2,3 , and Kai-Hsiang Chuang 1
1
Singapore BioImaging Consortium, Agency for
Science, Technology and Research, Singapore, Singapore,
2
Translational
Laboratory in Genetic Medicine, Agency for Science,
Technology and Research, Singapore, Singapore,
3
Department
of Medicine, National University of Singapore,
Singapore, Singapore
Longitudinal structural MRI was conducted to track
morphological changes in presymptomatic YAC128
Huntington disease (HD) mice. YAC128 mice, relative to
wild-type, showed progressive atrophy of the striatum
and white matter tracts starting from 1.5 months, while
cortical atrophy was found only at 6 months. The
progressive atrophy in striatum at very early age
indicates the vulnerable areas. The neurodegeneration
pattern identified will be useful for evaluation of
preclinical treatment trials of HD.
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