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Abstract #2080

Altered cerebrovascular reactivity and its restoration with Interferon beta treatment in multiple sclerosis

Marek Allen 1 , Valentina Tomassini 2 , Nikolaos Petsas 3 , Marco Carni 3 , Emilia Sbardella 3 , Kevin Murphy 1 , Patrizia Pantano 3 , Carlo Pozzilli 3 , and Richard Wise 1

1 CUBRIC, School of Psychology, Cardiff University, Cardiff, Cardiff, United Kingdom, 2 School of Medicine, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff, Cardiff, United Kingdom, 3 Department of Neurology and Psychiatry, Sapienza University of Rome, Rome, Italy

Cerebrovascular reactivity (CVR) is the capacity of blood vessels to increase blood flow to brain tissue, a process essential for preserved neurovascular coupling. Using breath hold-induced hypercapnia we aimed to investigate CVR in multiple sclerosis patients and the effect of interferon-beta treatment. We discovered a reduced reactivity in patients compared with healthy controls independent of distributed grey matter density reductions. This was reversed following commencement of interferon-beta1a treatment to a level comparable with controls. The effect of immunomodulation on CVR in patients suggests altered CVR is related to MS inflammatory activity and could indicate a marker for early therapeutic effect.

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