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Abstract #2081

Thalamic activation during verbal encoding is related to episodic memory in MS

Katherine A Koenig 1 , Ken E Sakaie 1 , Mark J Lowe 1 , Jian Lin 1 , Erik B. Beall 1 , Stephen M Rao 2 , Lael Stone 2 , Robert Bermel 2 , Bruce D Trapp 3 , and Micheal D Phillips 1

1 Imaging Sciences, The Cleveland Clinic, Cleveland, OH, United States, 2 Neurological Institute, The Cleveland Clinic, Cleveland, OH, United States, 3 Neurosciences, The Cleveland Clinic, Cleveland, OH, United States

We investigate functional activation during the encoding phase of an episodic memory task in 16 healthy controls and 32 multiple sclerosis (MS) patients, 16 with intact cognition and 16 with impaired episodic memory. MS patients with impaired episodic memory showed lower thalamic activation during encoding of correct words, and mean signal in the left thalamus was related to episodic memory performance and thalamic volume in MS patients but not controls. A larger sample and longitudinal measures are required to clarify the temporal relationship of functional activation, thalamic atrophy, and cognitive performance in MS.

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