Meeting Banner
Abstract #2079

Multi-Parametric qBOLD Approach for Robust Oxygen Extraction Fraction Quantification in Clinical Use

Sebastian Domsch 1 , Frederik Wenz 2 , and Lothar Rudi Schad 1

1 Computer Assisted Clinical Medicine, Heidelberg University, Mannheim, Baden-Wrttemberg, Germany, 2 Department of Radiation Oncology, Heidelberg University, Mannheim, Baden-Wrttemberg, Germany

The quantitative blood oxygenation level-dependent (qBOLD) approach, based on the tissue model, has facilitated promising in-vivo results using MRI. Thereby, the oxygen extraction fraction (OEF) is of great clinical interest providing a parameter for brain tissue viability or monitoring radio and chemo therapy. However, the qBOLD approach has not become clinically established yet due to numerous fit-parameters in the tissue model requiring high SNR or long measurement times clinically not available. In this work, a multi-parametric qBOLD approach is proposed to obtain robust OEF maps within clinical acquisition times using separate MR sequences to reduce the number of unknown fit-parameters.

This abstract and the presentation materials are available to members only; a login is required.

Join Here