Abstract #2079
Multi-Parametric qBOLD Approach for Robust Oxygen Extraction Fraction Quantification in Clinical Use
Sebastian Domsch 1 , Frederik Wenz 2 , and Lothar Rudi Schad 1
1
Computer Assisted Clinical Medicine,
Heidelberg University, Mannheim, Baden-Wrttemberg,
Germany,
2
Department
of Radiation Oncology, Heidelberg University, Mannheim,
Baden-Wrttemberg, Germany
The quantitative blood oxygenation level-dependent (qBOLD)
approach, based on the tissue model, has facilitated
promising in-vivo results using MRI. Thereby, the oxygen
extraction fraction (OEF) is of great clinical interest
providing a parameter for brain tissue viability or
monitoring radio and chemo therapy. However, the qBOLD
approach has not become clinically established yet due
to numerous fit-parameters in the tissue model requiring
high SNR or long measurement times clinically not
available. In this work, a multi-parametric qBOLD
approach is proposed to obtain robust OEF maps within
clinical acquisition times using separate MR sequences
to reduce the number of unknown fit-parameters.
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