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Abstract #2078

BBB Breakdown due to Axonal Degeneration: A Potential Confounding Factor for MS Diagnosis

Shu-Wei Sun 1,2 , Christopher Nishioka 3 , Steven Kaspick 4 , Chen-Fang Chung 4 , JoAnn Park 4 , and Hsiao-Fang Liang 4

1 Loma Linda University, Loma Linda, CA, United States, 2 University of California, Riverside, Riverside, CA, United States, 3 University of California, Riverside, CA, United States, 4 Loma Linda University, CA, United States

Retina ischemia caused axonal degeneration along optic nerve (ON) and tract (OT) of WldS and wild-type, while the damage was delayed in WldS. In WldS, ON and OT showed significant reductions of axial diffusivity in weeks 1 and 2, respectively, which provided us the time window of distinguished injure severity between the proximal (ON) and distal sections (OT) of RGC axons. Gd-T1WI and Evans blue both showed significant BBB leakage in RI-affected ON and OT beginning at week 1 in WldS mice. The remote BBB leakage may be observed in Gd-T1WI and may confuse the MS diagnosis.

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