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Abstract #2075

Intralesional vein shrinking in multiple sclerosis lacks in severeness -preliminary results from a 7T MRI study

Katharina Mller 1 , Joseph Kuchling 1 , Ivan Bozin 1 , Jan Drr 1 , Caspar Pfueller 1 , Lutz Harms 2 , Thoralf Niendorf 3 , Friedemann Paul 1 , Tim Sinnecker 1,4 , and Jens Wuerfel 1,5

1 Neurocure Research Center, Berlin, Berlin, Germany, 2 Department of Neurology, Charit Universittsmedizin Berlin, Berlin, Berlin, Germany, 3 Berlin Ultrahigh Field Facility (B.U.F.F), Max Delbrueck Center for Molecular Medicine, Berlin, Berlin, Germany, 4 Asklepios Fachklinikum Teupitz, Brandenburg, Germany, 5 Institute of Neuroradiology, University Medicine Goettingen, Goettingen, Germany

Vascular alterations in multiple sclerosis (MS) have been described decades ago. T2* weighted ultrahigh field MRI at 3 Tesla (T) visualized shrinked brain veins within MS plaques in vivo. However, this observation may be influenced by partial volume effects. We addressed this issue by developing a novel quantification algorithm and a novel MR-post processing procedure that generates susceptibility weighted turbo inversion recovery magnitude (sTIRM) images. We observed less intralesional venous shrinking on sTIRM compared to T2* weighted FLASH imaging. Our results confirm initial reports showing venous shrinking within MS lesions that is probably not as severe as expected.

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