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Abstract #2074

Multicontrats MRI improved the clinico-radiological correlation in early multiple sclerosis patients with minor deficits

Guillaume Bonnier 1,2 , Alexis Roche 1,3 , David Romanasco 4 , Samanta Simioni 2 , Djalel-Eddine Meskaldji 4 , David Rotzinger 3 , Ying-Chia Lin 5 , Gloria Menegaz 5 , Myriam Schluep 2 , Renaud Du Pasquier 2 , Tilman Johannes Sumpf 6 , Jens Frahm 6 , Jean-Philippe Thiran 4 , Gunnar Krueger 1,7 , and Cristina Granziera 1,2

1 Advanced Clinical Imaging technology group, Siemens-CIBM, EPFL, Lausanne, Vaud, Switzerland, 2 Department of Clinical Neurosciences, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Vaud, Switzerland, 3 Department of Radiology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Vaud, Switzerland, 4 STI / IEL / LTS5, EPFL, Lausanne, Vaud, Switzerland, 5 Dept. of Computer Science, University of Verona, Itlay, Italy, 6 Biomedizinische NMR Forschungs GmbH, Max Planck Institute for Biophysical Chemistry, Gottingen, Germany, Germany, 7 Healthcare Sector IM&WS S, Siemens Schweiz AG, Suisse, Switzerland

Conventional magnetic resonance imaging (MRI) of patients with multiple sclerosis provides only limited insights into the nature of brain tissue damage with modest clinical-radiological correlations. In this study, quantitative and semi-quantitative MRI techniques (T1, T2, T2*, MTR) were applied to study the potential of the MRI-accessible microstructural information to predict cognitive and motor scores in patients. A multiparametric analysis of whole brain abnormalities showed that MRI measures of microstructural alterations lead to significant improvement in clinical-radiological correlations even in the presence of minor functional deficits.

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