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Abstract #2070

Longitudinal mixed-effect model analysis of the association between global and tissue specific brain atrophy and lesion accumulation in patients with CIS

Mihael Varosanec 1 , Dana Horakova 2 , Jesper Hagemeier 1 , Niels Bergsland 1 , Michaela Tyblova 2 , Zdenek Seidl 3 , Manuela Vaneckova 3 , Jan Krasensky 3 , Michael G. Dwyer 1 , Eva Havrdova 2 , and Robert Zivadinov 1

1 Buffalo Neuroimaging Analysis Center, Department of Neurology, University at Buffalo SUNY, Buffalo, NY, United States, 2 Department of Neurology and Center of Clinical Neuroscience, Charles University in Prague, Prague, Czech Republic, 3 Department of Radiology, First Faculty of Medicine and General University Hospital, Charles University in Prague, Prague, Czech Republic

We investigated accumulation of new brain lesion, lesion volume, and contrast enhancing lesions with respect to the atrophy of gross brain structures in patients with clinically isolated syndrome. Longitudinal linear and quadratic mixed effect model analyses were performed for each time point and in dual directions. The more robust inverse mixed-effect model results suggest that the level of brain atrophy can explain T2 lesion accumulation better than the T2 lesion accumulation can explain accumulation of brain atrophy. These results suggests that close monitoring of brain volume changes may be relevant for identifying patients at risk for MS conversion.

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