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Abstract #2071

Analysis of Inhomogeneous Magnetization Transfer Applied In Patients with Multiple Sclerosis

Gopal Varma 1 , Mohit Neema 2 , Fotini S Papadopoulou 1 , Shahamat Tauhid 2 , Rohit Bakshi 2 , and David C Alsop 1

1 Radiology, Division of MR Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States, 2 Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States

The apparent specificity of inhomogeneous magnetization transfer (IHMT) to myelinated tissue lends itself to study in pathologies related to myelin loss. A preliminary results from IHMT applied in patients with multiple sclerosis (MS) are reported. A statistically significant difference is found from the IHMT ratio in comparison with a group of healthy volunteers for a posterior region of interest. The difference within this region is less significant in analysis of the more commonly used MT ratio. IHMT might therefore provide a potential improvement over MT in analysis of MS and other myelin related diseases.

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