Magnetization Transfer Saturation per TR (MTsat) better discriminates Normal-Appearing White Matter than Magnetization Transfer Ratio (MTR) in Multiple Sclerosis
Rexford Newbould 1,2 , Charlotte Thomas 3 , Rebecca Quest 4 , Jean Lee 3 , Lesley Honeyfield 4 , Alessandro Colasanti 1,3 , Paul Matthews 3,5 , Adam Waldman 4 , and Paolo Muraro 3,6
Imanova Centre for Imaging Sciences, London,
Medicine, Imperial College London, London, United
Sciences, Imperial College London, London, United
Imperial College London, London, United Kingdom,
GlaxoSmithKline R&D, London, United Kingdom,
Neurosciences, Imperial College London, London, United
MT saturation per TR (MTsat) has been proposed as a more
quantified measure of magnetization transfer than MTR.
Here, we acquired MTsat and MTR maps in 38 MS subjects
and 13 healthy controls, outlined white and grey matter
lesions on co-registered MPRAGE and T2w-FLAIR volumes.
Both MT contrasts highlighted T1 and T2-visible lesions
well. Normal-appearing white matter in controls and MS
subjects did not differ in the MTR maps, but did
strongly in MTsat maps. MTsat might be highlighting
early NAWM degeneration in these MS subjects.
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