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Abstract #2069

Magnetization Transfer Saturation per TR (MTsat) better discriminates Normal-Appearing White Matter than Magnetization Transfer Ratio (MTR) in Multiple Sclerosis

Rexford Newbould 1,2 , Charlotte Thomas 3 , Rebecca Quest 4 , Jean Lee 3 , Lesley Honeyfield 4 , Alessandro Colasanti 1,3 , Paul Matthews 3,5 , Adam Waldman 4 , and Paolo Muraro 3,6

1 Imanova Centre for Imaging Sciences, London, United Kingdom, 2 Experimental Medicine, Imperial College London, London, United Kingdom, 3 Brain Sciences, Imperial College London, London, United Kingdom, 4 Imaging, Imperial College London, London, United Kingdom, 5 Neurosciences, GlaxoSmithKline R&D, London, United Kingdom, 6 Clinical Neurosciences, Imperial College London, London, United Kingdom

MT saturation per TR (MTsat) has been proposed as a more quantified measure of magnetization transfer than MTR. Here, we acquired MTsat and MTR maps in 38 MS subjects and 13 healthy controls, outlined white and grey matter lesions on co-registered MPRAGE and T2w-FLAIR volumes. Both MT contrasts highlighted T1 and T2-visible lesions well. Normal-appearing white matter in controls and MS subjects did not differ in the MTR maps, but did strongly in MTsat maps. MTsat might be highlighting early NAWM degeneration in these MS subjects.

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