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Abstract #2067

Direct Detection of Myelin Using Zero-Echo Time (ZTE) Imaging in Lamb Spinal Cord

Cheng Li 1 , Alan C. Seifert 1 , Suzanne L. Wehrli 2 , Michael J. Wilhelm 3 , David B. Hackney 4 , and Felix W. Wehrli 1

1 Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2 NMR Core Facility, Childrens Hospital of Philadelphia, Philadelphia, PA, United States, 3 Chemistry, Temple University, Philadelphia, PA, United States, 4 Radiology, Harvard Medical School, Boston, MA, United States

Direct assessment of myelin would reveal central nervous system (CNS) abnormalities and enhance our understanding of neurological diseases. Our previous work demonstrated that myelin can be directly imaged on a 9.4T NMR laboratory spectrometer/imaging system with ultra-short echo time (UTE) imaging. However, the extremely short T2 values (~100s) and relatively low proton density of myelin limit its detectability on clinical scanner. In this work, we demonstrate the feasibility of quantitative zero-echo time (ZTE) imaging of reconstituted extracted myelin and intact lamb spinal cord at 9.4T and on a 3T whole-body scanner.

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