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Abstract #2066

Comparison of Three Putative MR Myelin Markers in Multiple Sclerosis Subjects and Healthy Controls

Irene Margaret Vavasour 1 , Shannon H Kolind 2 , Alexander Rauscher 1 , Roger Tam 1 , Nicholas Seneca 3 , David Leppert 3 , Alex L MacKay 1,4 , David KB Li 1 , and Anthony L Traboulsee 2

1 Radiology, University of British Columbia, Vancouver, BC, Canada, 2 Medicine (Neurology), University of British Columbia, Vancouver, BC, Canada, 3 F. Hoffmann-La Roche Ltd., Switzerland, 4 Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada

This study compared the results obtained from 3 quantitative MRI measurements (magnetization transfer ratio (MTR), myelin water fraction (MWF) and fraction of myelin signal from steady state imaging (fM)) in white matter from subjects with MS and healthy controls. The 3 putative myelin MRI markers demonstrate reduction across structures in MS compared to controls however, MWF demonstrated the largest decreases and range of differences between structures. All 3 metrics followed the same pattern showing the greatest decreases in the ILF, followed by the CC, SLF, MN and finally CST. The strongest correlation between metrics was found between MWF and fM.

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