Abstract #2066
Comparison of Three Putative MR Myelin Markers in Multiple Sclerosis Subjects and Healthy Controls
Irene Margaret Vavasour 1 , Shannon H Kolind 2 , Alexander Rauscher 1 , Roger Tam 1 , Nicholas Seneca 3 , David Leppert 3 , Alex L MacKay 1,4 , David KB Li 1 , and Anthony L Traboulsee 2
1
Radiology, University of British Columbia,
Vancouver, BC, Canada,
2
Medicine
(Neurology), University of British Columbia, Vancouver,
BC, Canada,
3
F.
Hoffmann-La Roche Ltd., Switzerland,
4
Physics
and Astronomy, University of British Columbia,
Vancouver, BC, Canada
This study compared the results obtained from 3
quantitative MRI measurements (magnetization transfer
ratio (MTR), myelin water fraction (MWF) and fraction of
myelin signal from steady state imaging (fM)) in white
matter from subjects with MS and healthy controls. The 3
putative myelin MRI markers demonstrate reduction across
structures in MS compared to controls however, MWF
demonstrated the largest decreases and range of
differences between structures. All 3 metrics followed
the same pattern showing the greatest decreases in the
ILF, followed by the CC, SLF, MN and finally CST. The
strongest correlation between metrics was found between
MWF and fM.
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