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Abstract #2050

Relationship of high-resolution diffusion tensor MRI measures of the cingulum bundle with cognitive function in multiple sclerosis

Katherine A Koenig 1 , Ken E Sakaie 1 , Mark J Lowe 1 , Jian Lin 1 , Erik B. Beall 1 , Stephen M Rao 2 , Lael Stone 2 , Robert Bermel 2 , Bruce D Trapp 3 , and Micheal D Phillips 1

1 Imaging Sciences, The Cleveland Clinic, Cleveland, OH, United States, 2 Neurological Institute, The Cleveland Clinic, Cleveland, OH, United States, 3 Neurosciences, The Cleveland Clinic, Cleveland, OH, United States

The current work uses DTI tractography to investigate the integrity of the posterior cingulate-entorhinal cortex in 57 subjects with Multiple Sclerosis (MS) and 17 controls. Subjects with MS showed pathologic DTI measures, and all DTI measures were related to measures of spatial episodic memory.

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