Relationship of high-resolution diffusion tensor MRI measures of the cingulum bundle with cognitive function in multiple sclerosis
Katherine A Koenig 1 , Ken E Sakaie 1 , Mark J Lowe 1 , Jian Lin 1 , Erik B. Beall 1 , Stephen M Rao 2 , Lael Stone 2 , Robert Bermel 2 , Bruce D Trapp 3 , and Micheal D Phillips 1
Imaging Sciences, The Cleveland Clinic,
Cleveland, OH, United States,
Institute, The Cleveland Clinic, Cleveland, OH, United
The Cleveland Clinic, Cleveland, OH, United States
The current work uses DTI tractography to investigate
the integrity of the posterior cingulate-entorhinal
cortex in 57 subjects with Multiple Sclerosis (MS) and
17 controls. Subjects with MS showed pathologic DTI
measures, and all DTI measures were related to measures
of spatial episodic memory.
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