Abstract #2051
Functional Relevance of White Matter Degradation in Multiple Sclerosis: A Tract-Based Spatial Meta-Analysis
Thomas Welton 1 , Dorothee Auer 1 , and Rob Dineen 1
1
Radiological Sciences Group, University of
Nottingham, Nottingham, Nottinghamshire, United Kingdom
Relevance of tract-specific white matter degradation to
clinical and cognitive functional status in multiple
sclerosis (MS) has been a focus of recent research, but
a consensus is yet to emerge. We present the first
voxelwise meta-analysis of tract-based spatial
statistics studies in MS, incorporating data across 8
studies and 358 patients. Our findings confirm
widespread reductions in tract FA in MS patients in
comparison to controls. Damage to white matter tracts in
the corpus callosum and posterior cingulum was
associated with elevated disability and cognition.
This abstract and the presentation materials are available to members only;
a login is required.
Join Here
