Abstract #2049
Increased microstructural damage in the normal appearing white matter appears to distinguish SPMS from RRMS
Yunyan Zhang 1 , Bailey Komishke 2 , Luanne Metz 3 , and Lenora Brown 3
1
University of Calgary, Calgary, AB, Canada,
2
University
of British Columbia, BC, Canada,
3
University
of Calgary, AB, Canada
To understand the mechanism relating to distinct
disability, we evaluated both macroscopic and
microscopic tissue change in advanced SPMS and mild RRMS,
with a focus on the corpus callosum. We found smaller
white matter volume, not gray matter, in SPMS than in
RRMS subjects but similar T2 lesion load. Also in SPMS,
corpus callosum was atrophic, where fractional
anisotropy and radial diffusivity was significantly
compromised. No difference between mild RRMS and
controls. Our results suggest the importance of NAWM and
early intervention may protect mild RRMS patients from
developing advanced disability.
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