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Abstract #2041

A statistical analysis to determine significant within-subject changes of BOLD MRI cerebrovascular reactivity to CO 2

Olivia Sobczyk 1 , Adrian Crawley 2 , Julien Poublanc 2 , Kevin Sam 2,3 , Daniel M. Mandell 2 , David Mikulis 2 , James Duffin 3,4 , and Joseph Fisher 3,4

1 Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada, 2 Department of Medical Imaging, University Health Network, Toronto, Ontario, Canada, 3 Department of Physiology, University of Toronto, Toronto, Ontario, Canada, 4 Anaesthesiology, University Health Network, Toronto, Ontario, Canada

Cerebrovascular reactivity (CVR), measured as the cerebral blood flow (e.g. BOLD MRI) response to a vasoactive stimulus (e.g. carbon dioxide), has been used to gauge neurovascular function. Despite uniform test conditions, between-test differences in CVR remain due to variations in normal physiology and in the measurement technology over time. We score test-to-test changes in CVR as the z-value derived from those of a cohort of healthy subjects tested on the same scanner. We demonstrate this approach identifies changes between tests that are unlikely to be attributed to physiology and technical variation, and thus attributed to interval change in pathology.

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