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Abstract #2035

Atypical BOLD fMRI response is co-localized with abnormal resting perfusion in patients with arteriovenous malformations

Erin L Mazerolle 1 , Roberta La Piana 2 , Donatella Tampieri 2 , Kelvin Mok 2 , Maria Cortes 2 , Denise Klein 2 , and G Bruce Pike 1

1 University of Calgary, Calgary, Alberta, Canada, 2 Montreal Neurological Institute, Montreal, Quebec, Canada

Pre-treatment mapping has become an established clinical application of blood oxygen level dependent (BOLD) fMRI. However, in patients with abnormal perfusion such as arteriovenous malformations (AVMs), it can be difficult to interpret BOLD results. We used arterial spin labelling (ASL) to evaluate whether perfusion information can clarify the interpretation of atypical fMRI responses in AVM patients. We found that atypical BOLD functional connectivity and activation was preferentially localized to regions of abnormally high perfusion. We propose that clinical applications of BOLD in patients with abnormal cerebral hemodynamics could greatly benefit from additional measurements such as ASL.

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