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Abstract #2034

[14C]2-Deoxyglucose autoradiography confirms metabolism within ischaemic penumbra identified by two complementary, PFC-enhanced dynamic MR imaging techniques

Graeme A Deuchar 1 , David Brennan 2 , William M Holmes 1 , Maria del Rosario Lopez Gonzalez 1 , Martin Shaw 3 , I Mhairi Macrae 1 , and Celestine Santosh 2

1 Institute of Neuroscience & Psychology, University of Glasgow, Glasgow, United Kingdom, 2 Institute of Neurological Sciences, Southern General Hospital, Glasgow, United Kingdom, 3 Clinical Physics, University of Glasgow, Glasgow, United Kingdom

Thrombolysis, the only licensed therapy for acute stroke remains under-utilised due to safety concerns concerning its use beyond the 4.5hr treatment-window Improved brain imaging would enable safer and wider treatment by identifying patients with salvageable brain tissue (penumbra) who would benefit from thrombolysis regardless of time. Existing imaging is inadequate and lacks diagnostic validation. GOLD (Glasgow-Oxygen-Level-Dependent) imaging uniquely employs MRI, hyperoxia and an oxygen-carrier perfluorocarbon (Oxycyte) to enhance metabolic differentiation of penumbra from irreversibly damaged tissue thereby providing clinicians with a stratified measure of tissue viability while also supporting penumbra survival through improved oxygenation (additional imaging time carries no penalty).

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