Abstract #2034
[14C]2-Deoxyglucose autoradiography confirms metabolism within ischaemic penumbra identified by two complementary, PFC-enhanced dynamic MR imaging techniques
Graeme A Deuchar 1 , David Brennan 2 , William M Holmes 1 , Maria del Rosario Lopez Gonzalez 1 , Martin Shaw 3 , I Mhairi Macrae 1 , and Celestine Santosh 2
1
Institute of Neuroscience & Psychology,
University of Glasgow, Glasgow, United Kingdom,
2
Institute
of Neurological Sciences, Southern General Hospital,
Glasgow, United Kingdom,
3
Clinical
Physics, University of Glasgow, Glasgow, United Kingdom
Thrombolysis, the only licensed therapy for acute stroke
remains under-utilised due to safety concerns concerning
its use beyond the 4.5hr treatment-window Improved
brain imaging would enable safer and wider treatment by
identifying patients with salvageable brain tissue
(penumbra) who would benefit from thrombolysis
regardless of time. Existing imaging is inadequate and
lacks diagnostic validation. GOLD
(Glasgow-Oxygen-Level-Dependent) imaging uniquely
employs MRI, hyperoxia and an oxygen-carrier
perfluorocarbon (Oxycyte) to enhance metabolic
differentiation of penumbra from irreversibly damaged
tissue thereby providing clinicians with a stratified
measure of tissue viability while also supporting
penumbra survival through improved oxygenation
(additional imaging time carries no penalty).
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