An artifact-free imaging protocol for the mapping of cerebrovascular reactivity.
Harshan Ravi 1,2 , Binu P Thomas 1,2 , Shin-lei Peng 1 , and Hanzhang Lu 1
Advanced Imaging Research Center, University
of Texas Southwestern Medical center, Dallas, Texas,
of Bioengineering, University of Texas at Arlington,
Arlington, Texas, United States
With a growing need for specific biomarkers in vascular
diseases, there has been a surging interest in mapping
cerebrovascular reactivity (CVR) of the brain. The
increase in CVR with CO2 inhalation is an expected
outcome, however recent studies reported apparent
negative CVR. This apparently negative CVR is
predominantly located in brain ventricles. This is
attributed to a dilation of blood vessels during CO2
inhalation, which displaces the bright CSF signal in
ventricle causing an artifactual reduction in BOLD
signal. In this work, we performed simulation and
experimental studies to re-optimize the BOLD imaging
parameters such that negative CVR is removed.
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