Abstract #2023
Cerebrovascular reactivity quantification in patients with intracranial stenosis before and after surgical revascularization
Carlos C. Faraco 1 , Lindsey M. Dethrage 1 , Meaghan A. Neill 2 , Lori C. Jordan 3 , Robert J. Singer 4 , J Mocco 5 , Paul F. Clemmons 6 , Manus J. Donahue 1,3 , and Megan K. Strother 1
1
Department of Radiology and Radiological
Sciences, Vanderbilt University, Nashville, TN, United
States,
2
The
Medical University of South Carolina, Charleston, SC,
United States,
3
Department
of Neurology, Vanderbilt University, Nashville, TN,
United States,
4
Section
of Neurosurgery, Geisel School of Medicine at Dartmouth,
Hanover, NH, United States,
5
Department
of Neurosurgery, Vanderbilt University, Nashville, TN,
United States,
6
Department
of Radiology Nursing, Vanderbilt University, Nashville,
TN, United States
Pre- and/or post-revascularization BOLD scans were
acquired on non-atherosclerotic intracranial stenosis
(i.e., Moyamoya disease) patients during hypercarbic
hyperoxic (carbogen; 5% CO2 / 95% O2) vascular
stimulation to demonstrate the effectiveness of BOLD
fMRI to longitudinally monitor CVR. Patients with pre-
and post-op scans continued to demonstrate significantly
improved (p<.001) CVR in the operative hemisphere at the
time of their second post-op scan (175 months post-op).
When all patients scans were grouped by time after
revascularization, significant (p<.001) improvements
were seen beginning at approximately one year post-op
and stabilized at approximately two years post-op.
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